Serum Immunoglobulin Levels (IgG, IgM, IgA, IgE)

Age	IgG (mg/dL)	IgM (mg/dL)	IgA (mg/dL)	IgE (IU/mL)
Cord blood (term)------	1121 (636–1606)----------	13 (6.3–25)----------	2.3 (1.4–3.6)----------	0.22 (0.04–1.28)----------
1 mo	503 (251–906)	45 (20–87)	13 (1.3–53)
6 wk				0.69 (0.08–6.12)
2 mo	365 (206–601)	46 (17–105)	15 (2.8–47)
3 mo	334 (176–581)	49 (24–89)	17 (4.6–46)	0.82 (0.18–3.76)
4 mo	343 (196–558)	55 (27–101)	23 (4.4–73)
5 mo	403 (172–814)	62 (33–108)	31 (8.1–84)
6 mo	407 (215–704)	62 (35–102)	25 (8.1–68)	2.68 (0.44–16.3)
7–9 mo	475 (217–904)	80 (34–126)	36 (11–90)	2.36 (0.76–7.31)
10–12 mo	594 (294–1069)	82 (41–149)	40 (16–84)
1 yr	679 (345–1213)	93 (43–173)	44 (14–106)	3.49 (0.80–15.2)
2 yr	685 (424–1051)	95 (48–168)	47 (14–123)	3.03 (0.31–29.5)
3 yr	728 (441–1135)	104 (47–200)	66 (22–159)	1.80 (0.19–16.9)
4–5 yr	780 (463–1236)	99 (43–196)	68 (25–154)	8.58 (1.07–68.9)[†]
6–8 yr	915 (633–1280)	107 (48–207)	90 (33–202)	12.89 (1.03–161.3)[‡]
9–10 yr	1007 (608–1572)	121 (52–242)	113 (45–236)	23.6 (0.98–570.6) [§]
14 yr				20.07 (2.06–195.2)
Adult	994 (639–1349)	156 (56–352)	171 (70–312)	13.2 (1.53–114)

† IgE data for 4 yr. ‡ IgE data for 7 yr. § IgE data for 10 yr.

Immunoglobulins Mayo.png

in mg/dL

Note

Serum IgG Subclass Levels

Age (yr)	IgG1 (mg/dL)	IgG2 (mg/dL)	IgG3 (mg/dL)	IgG4 (mg/dL)
0.5–1-- ----	290 (140–620)----------	58 (41–130)----------	41 (11–85)----------	0.2 (0–0.8)----------
1–1.5	350 (170–650)	62 (40–140)	42 (12–87)	3 (0–26)
1.5–2	400 (220–720)	80 (50–180)	44 (14–91)	7 (0–41)
2–3	450 (240–780)	95 (55–200)	46 (15–93)	14 (0–69)
3–4	480 (270–810)	115 (65–220)	48 (16–96)	20 (1–94)
4–6	500 (300–840)	130 (70–250)	50 (17–97)	26 (2–116)
6–9	570 (350–910)	170 (85–330)	54 (20–100)	37 (3–158)
9–12	600 (370–930)	210 (10–400)	58 (22–109)	47 (4–190)
12–18	580 (370–910)	260 (110–480)	63 (24–116)	49 (5–196)
Adult	500 (280–800)	300 (115–570)	64 (24–120)	35 (5–125)

Age of healthy donors	IgG g/L	IgG1 g/L	IgG2 g/L	IgG3 g/L	IgG4 g/L	IgA g/L	IgA1 g/L	IgA2 g/L	IgM g/L
0– <5 months	1.0–1.34	0.56–2.15	≤0.82	0.07.6–8.23	≤ 0.198	0.07–0.37	0.10–0.34	0.004–0.055	0.26–1.22
5– <9 months	1.64–5.88	1.02–3.69	≤ 0.89	0.119–0.740	≤ 0.208	0.16–0.50	0.14–0.41	0.015–0.062	0.32–1.32
9– <15 months	2.46–9.04	1.60–5.62	0.24–0.98	0.173–0.637	≤ 0.220	0.27–0.66	0.20–0.50	0.028–0.070	0.40–1.43
15– <24 months	3.13–11.70	2.09–7.24	0.35–1.05	0.219–0.550	≤ 0.230	0.36–0.79	0.24–0.58	0.039–0.077	0.46–1.52
2– <4 years	2.95–11.56	1.58–7.21	0.39–1.76	0.170–0.847	0.004–0.491	0.27–2.46	0.16–1.62	0.013–0.311	0.37–1.84
4– <7 years	3.86–14.70	2.09–9.02	0.44–3.16	0.108–0.949	0.008–0.819	0.29–2.56	0.17–1.87	0.011–0.391	0.37–2.24
7– <10 years	4.62–16.82	2.53–10.19	0.54–4.35	0.085–10.26	0.010–1.087	0.34–2.74	0.21–2.21	0.014–0.480	0.38–2.51
10– <13 years	5.03–15.80	2.80–10.30	0.66–5.02	0.115–10.53	0.010–1.219	0.42–2.95	0.27–2.50	0.026–0.534	0.41–2.55
13– <16 years	5.09–15.80	2.89–9.34	0.82–5.16	0.200–10.32	0.007–1.217	0.52–3.19	0.36–2.75	0.047–0.551	0.45–2.44
16– <18 years	4.87–13.27	2.83–7.72	0.98–4.86	0.313–0.976	0.003–1.110	0.60–3.37	0.44–2.89	0.066–0.543	0.49–2.01
≥18 years	7.67–15.90	3.41–8.94	1.71–6.32	0.184–10.60	0.024–1.210	0.61–3.56	0.50–3.14	0.097–1.560	0.37–2.86

Total serum IgE (IU/mL)

Age	Gender	Geometric mean	Upper 95% confidence limit
6–14 years	M F	42.7 43.3	527 344
15–24 years	M F	33.6 18.6	447 262
25–34 years	M F	16.8 16.6	275 216
35–44 years	M F	21.7 19.3	242 206
45–54 years	M F	19.2 13.3	254 177
55–64 years	M F	21.3 11.7	354 148
65–74 years	M F	21.2 11.5	248 122
>75 years	M F	18.4 9.2	219 124
6–75 years	all M all F	22.9 14.7	317 189

Serum levels of IgE greater than +1SD for age would be consistent with the presence of allergic disease

Note:

1 IU/mL = 2.4 ng/mL
1 kUA/L of specific IgE has been shown to be equivalent to 1 kU/L of total IgE in the ImmunoCAP system

(10th to 90th percentile)

Age	CD3 Count (%)	CD4 count (%)	CD8 Count (%)	CD19 Count (%)
0–3 mo-------	2.50–5.50 (53–84)----------	1.60–4.00 (35–64)----------	0.56–1.70 (12–28)----------	0.12–2.10 (14–76)
3–6 mo	2.50–5.60 (51–77)	1.80–4.00 (35–56)	0.59–1.60 (12–23)	0.00–2.80 (00–84)
6–12 mo	1.90–5.90 (49–76)	1.40–4.30 (31–56)	0.50–1.70 (12–24)	0.02–2.30 (01–80)
1–2 yr	2.10–6.20 (53–75)	1.30–3.40 (32–51)	0.62–2.00 (14–30)	0.00–2.30 (00–80)
2–6 yr	1.40–3.70 (56–75)	0.70–2.20 (28–47)	0.49–1.30 (16–30)	0.02–1.40 (02–76)
6–12 yr	1.20–2.60 (60–76)	0.65–1.50 (31–47)	0.37–1.10 (18–35)	0.00–0.74 (00–67)
12–18 yr	1.00–2.20 (56–84)	0.53–1.30 (31–52)	0.33–0.92 (18–35)	0.00–0.39 (00–60)
Adult	0.70–2.10 (55–83)	0.30–1.40 (28–57)	0.20–0.90 (10–39)	0.10–0.50 (6–19)

Absolute counts (number of cells per microliter × 10-3)

Numbers in parentheses are the 95% confidence intervals

	Blood absolute eosinophil count (x 10^9/L)---	Blood absolute eosinophil count (/mm3)---
Normal -------	<0.5 (often <5% of leukocytes)	<500
Eosinophilia	>0.5	>500
Mild	>0.5-1.5	>500-1500
Hypereosinophilia-----	>1.5	>1500
Moderate hypereosinophilia-----	>1.5-5	>1500-5000
Severe hypereosinophilia-----	>5	>5000

Blood eosinophil count >1.5 x 10^9 is classically considered the level above which organ damage is more likely to occur
- Note that tissue eosinophilia with potential for organ damage may be present with a normal blood count, and vice versa
- Eosinophil count may be suppressed (masked) by endogenous (e.g. cortisol stress response to infection) or exogenous corticosteroids

Standard clinical assay measures total tryptase (sum of pro and mature forms of alpha and beta tryptase) and reflects total mast cell number + mast cell degranulation (assay for mature tryptase reflecting pure mast cell degranulation in not available clinically)
Median serum tryptase levels are highest in infants under 3 mo (6.12±3.47 mcg/L) and gradually fall to pediatric/adult levels by 9-12 months (3.85 ± 1.8 mcg/L)
Atopy is associated with even higher tryptase levels in infants <3 mo (14.20±10.22 mcg/L)